Microphysiological Systems for AD<\/h1><\/div>Two Centers developing standardized 2D and 3D MPS models to advance precision medicine for Alzheimer’s Disease<\/b><\/p>\n<\/div>Mass General Brigham<\/span><\/a><\/div>Indiana University<\/span><\/a><\/div><\/div><\/div><\/div>Mass General Brigham & Partners<\/span><\/a><\/div>MPS-AD Indiana University School of Medicine<\/span><\/a><\/div><\/div><\/div><\/div><\/div>Mission Statement<\/h2><\/div><\/div><\/div>We are developing reproducible and scalable 2D and 3D Micro-Physiological System (MPS) models that recapitulate key features of human AD and ADRD pathophysiology. These platforms will be used as precision medicine research tools to investigate complex AD biology and to accelerate drug discovery and preclinical drug development.<\/h6>\nGoals: <\/strong><\/h6>\n\n- Develop standardized and well characterized 2D and 3D MPS models of AD\/ADRD <\/span><\/li>\n
- Validity the ability of the models to recapitulate key translational features of AD\/ADRD across molecular, biochemical, cellular and histological phenotypes<\/span><\/li>\n
- Develop methods for rigorous preclinical efficacy and safety testing and identify readouts that can serve as biomarkers of target engagement, safety, and efficacy<\/span><\/li>\n
- Ensure rapid and broad distribution of the models, data, and methods for use in basic research and therapeutic development<\/li>\n<\/ul>\n
Contact Us:<\/strong><\/h6>\n\n- IU MPS-AD Center<\/span><\/a><\/li>\n
- MGB MPS-AD Center<\/a><\/li>\n<\/ul>\n<\/div><\/div><\/div>Mass General Brigham<\/span><\/a><\/div>Indiana University<\/span><\/a><\/div><\/div><\/div><\/div>MPS-AD Indiana University School of Medicine<\/span><\/a><\/div>Mass General Brigham & Partners<\/span><\/a><\/div><\/div><\/div>
Two Centers developing standardized 2D and 3D MPS models to advance precision medicine for Alzheimer’s Disease<\/b><\/p>\n<\/div>Mission Statement<\/h2><\/div>
We are developing reproducible and scalable 2D and 3D Micro-Physiological System (MPS) models that recapitulate key features of human AD and ADRD pathophysiology. These platforms will be used as precision medicine research tools to investigate complex AD biology and to accelerate drug discovery and preclinical drug development.<\/h6>\n
Goals: <\/strong><\/h6>\n
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Contact Us:<\/strong><\/h6>\n
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